The Villa Brignole Sale was built during the 16th and 17th centuries in the Voltri region of Genoa, at the edge of the Grande Genova. The villa underwent restoration work in the 19th Century, at the request of the owner Maria Brignole Sale, the Duchess of Galliera. She was a benefactor of the city and had furnished the Palazzo Bianchi and Palazzo Rosso with their respective art collections. The duchess bequeathed the villa and the park surrounding it to the city along with large amounts of money to charitable trusts.